Why the study?
Does candesartan improve cognitive function in a type-2 diabetic mouse model?
Population
Type-2 diabetic mouse model, KK-A(y) mice, and age-matched C57BL6 mice
Comparison
Oral administration of candesartan at a… vs Untreated KK-A(y) mice and age-matched C57BL6 mice
Design
Preclinical
Follow-up
from 8 weeks to at least 14 weeks of age
Authors
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Supports further study of candesartan for cognition in diabetes; should not yet change clinical practice.
Does candesartan improve cognitive function in a type-2 diabetic mouse model?
Candesartan ameliorates cognitive impairment in a type-2 diabetic mouse model, potentially via neuroprotective factor upregulation and improved glucose tolerance.
Tsukuda et al. (2007) studied this question.