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Theoretical modeling reveals dynamic hormonal shifts unmask latent genetic vulnerabilities across lifespan transitions, indicating risk from temporal handoff failure.
How do major lifespan transitions unmask hidden genetic vulnerabilities? This paper introduces the Endocrine-Chronobiological Axis, establishing hormone profiles as time-varying, internal modifiers of an organism's biological operating range. It reframes hormones from static cross-sectional values into highly timed, dynamic signals that alter tissue mechanics, chromatin accessibility, and regenerative reserve. Evaluating puberty, pregnancy, and menopause as non-linear state transitions, the model utilizes cutting-edge 2026 data on tissue remodeling to map how moving endocrine conditions trigger temporal handoff failure and terrain carryover.
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Jacqueline J. Horsford (2026) studied this question.
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