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Ordinarily, the history and physical examination and routine tests, including thyroid function tests, iodine 123 or technetium Tc 99m scans, and echography, will determine the best therapeutic approach to a solitary thyroid nodule. In the case of an asymptomatic, hypofunctional solid nodule, thyroid hormone suppression and fine-needle aspiration biopsy may be necessary to further delineate the best therapy.
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Ernest L. Mazzaferri (1981) studied this question.
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