Key result
Global illumination at low light intensities terminates cardiac spiral waves slowly via progressive dissolution of the core and action potential prolongation.
Why the study?
Defibrillation typically terminates spiral waves immediately with high-voltage shocks, but slow termination over a finite period of time also occurs and its underlying dynamics are not fully understood.
Low-energy optogenetic defibrillation terminates spiral waves slowly via core dissolution and action potential prolongation, offering mechanistic insights for developing low-energy defibrillation techniques.
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May guide low-intensity optogenetic arrhythmia termination in models; leaves open experimental and clinical translation.
Hussaini et al. (2023) studied Ventricular arrhythmia (n=5). Global optical illumination vs. High light intensities was evaluated on Termination of spiral waves. Global illumination at low light intensities terminates cardiac spiral waves slowly via progressive dissolution of the core and action potential prolongation.
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