Why the study?
Does the application of external electrical fields terminate spiral waves in isolated canine ventricular tissue?
Does the application of external electrical fields terminate spiral waves in isolated canine ventricular tissue?
High-speed optical imaging demonstrates that spiral waves in canine ventricular tissue can be consistently terminated by external electrical fields >7 V/cm that simultaneously depolarize tissue to >30% of normal action potential amplitude.
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External fields terminate spiral waves in isolated tissue; hypothesis-generating for defibrillation mechanisms, in vivo validation required before clinical consideration.
Fishler et al. (2002) studied this question.
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