Key result
Doxazosin treatment in normotensive subjects decreased daytime diastolic blood pressure by 3 mmHg and caused apparent nighttime tachycardia.
Why the study?
Does doxazosin alter ambulatory blood pressure and pulse rate in normotensive subjects?
Does doxazosin alter ambulatory blood pressure and pulse rate in normotensive subjects?
Mean Difference: 3
In normotensive subjects, doxazosin up to 8 mg/day causes slight daytime diastolic hypotension and apparent nighttime tachycardia.
Should not change practice in normotensives; leaves open clinical relevance and need for randomized confirmation.
The effect of long-term doxazosin treatment on normotensive subjects was evaluated by 48-hour ambulatory blood pressure (BP) monitoring (ABPM). Eight normotensive volunteers were given 1 mg of doxazosin per day, and the dose was titrated every week up to 8 mg/day. The 48-hour ABPM, using a noninvasive device, was performed before treatment and during the 4th week of treatment. Doxazosin did not decrease the average 48-hour systolic BP, but diastolic BP decreased slightly (3 mmHg). This slight decrease in 48-hour diastolic BP was observed during the daytime. The 48-hour pulse rate (PR) was clearly elevated by doxazosin, which was attributed to tachycardia at night. Thus, the present study using 48-hour ABPM indicated that long-term doxazosin treatment may result in only slight daytime hypotension with apparent nighttime tachycardia in normotensive subjects.
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TAKATA et al. (1994) studied Normotension (n=8). Doxazosin vs. Baseline (before treatment) was evaluated on 48-hour ambulatory blood pressure (3 mmHg decrease in diastolic BP). Doxazosin treatment in normotensive subjects decreased daytime diastolic blood pressure by 3 mmHg and caused apparent nighttime tachycardia.
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