Key result
Doxazosin transiently lowers supine systolic BP and cortisol vs placebo, but increases pulse rate.
Why the study?
The acute haemodynamic and hormonal effects of oral doxazosin in normal subjects were not well characterized.
Does oral doxazosin 2 mg alter haemodynamic and hormonal parameters compared to placebo in normal men?
RCT (n=6)
Does oral doxazosin 2 mg alter haemodynamic and hormonal parameters compared to placebo in normal men?
Acute administration of 2 mg oral doxazosin in normal men transiently lowers supine systolic blood pressure and cortisol at 4 hours, while increasing pulse rate after 6 hours.
Should not guide clinical use in patients; leaves open relevance of acute effects to hypertension or cardiovascular populations.
Haemodynamic and hormonal effects of doxazosin, a long-acting alpha 1-adrenoceptor antagonist (2 mg) were compared with placebo in six normal men. Doxazosin at 2 mg produced lower supine systolic blood pressure and plasma cortisol concentration than control at 4 h only, but these changes were not sustained. Both supine and standing pulse rate were increased by active drug after 6 h. In this acute study doxazosin did not affect plasma renin or aldosterone concentrations.
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Whitworth et al. (1987) conducted an RCT in Healthy volunteers (n=6). Doxazosin vs. Placebo was evaluated on Haemodynamic and hormonal effects. Doxazosin 2 mg transiently lowered supine systolic blood pressure and plasma cortisol at 4 hours compared with placebo, and increased pulse rate after 6 hours.
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