Key result
MitraClip repair in functional versus degenerative mitral regurgitation showed similar 5-year survival (53.5% vs 57.1%, P=0.087) and comparable rates of severe residual regurgitation.
Why the study?
Real-world mid-term outcomes of percutaneous edge-to-edge mitral repair were still limited.
Cohort (n=339)
No
Absolute Event Rate: 53.5% vs 57.1%
p-value: p=0.087
In a real-world setting, percutaneous edge-to-edge mitral repair provided sustained symptom benefit and freedom from severe MR at 5 years in both functional and degenerative MR, though overall 5-year survival was approximately 50%.
Supports consideration of MitraClip in both MR types; extends real-world data but leaves open randomized confirmation of equivalence.
OBJECTIVES: To report mid-term results after MitraClip repair, according to mitral regurgitation (MR) mechanism, in a real-world single-center experience. BACKGROUND: Mid-term outcomes of percutaneous edge-to-edge mitral repair in the real world are still limited. METHODS: We assessed the follow-up results of patients treated with MitraClip at a single high-volume mitral center from 2008 to 2016. All patients underwent Heart-Team discussion, prospective data collection and enrolment in a dedicated outpatient clinic. Functional (FMR, n = 242, 68.6%) and degenerative (DMR, n = 97, 27.5%) MR patients were separately analyzed. RESULTS: 5-Year survival was 53.5 ± 4.5% in FMR vs 57.1 ± 7.5% in DMR (P = 0.087). Reduced survival was strongly associated with worse left ventricle remodeling (ESV HR 1.01, CI 1.01-1.02, P < 0.001) in FMR, and with worse symptoms (New York Heart Association IV HR 6.72, CI 1.78-25.45, P = 0.005) in DMR. 5-Year cumulative incidence function for MR ≥ 3 was 23.7 ± 3.4% in FMR vs 27.9 ± 5.9% in DMR (P = 0.39), being associated with residual MR = 2 both in FMR (HR 4.67, CI 2.49-8.74, P < 0.001) and DMR (HR 7.15, CI 2.72-18.75, P < 0.001). At 5-year, patients in NYHA class I-II increased from 17.9% to 45.3% in FMR (P < 0.001) and from 33.3% to 51.3% in DMR (P < 0.001). CONCLUSIONS: In this single-center real-world experience, 5-year after MitraClip, half of the patients were alive and 3/4 were free from MR, both in FMR and DMR. Symptoms benefit was sustained in both groups. Advanced ventricular remodeling, advanced symptoms, and suboptimal MR reduction were associated with worse results. Refined patient selection, improved efficacy and more data will be all required to improve long-term outcomes.
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Buzzatti et al. (2018) conducted a cohort in Mitral regurgitation (n=339). MitraClip repair in functional mitral regurgitation vs. MitraClip repair in degenerative mitral regurgitation was evaluated on 5-year survival (p=0.087). MitraClip repair in functional versus degenerative mitral regurgitation showed similar 5-year survival (53.5% vs 57.1%, P=0.087) and comparable rates of severe residual regurgitation.
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