Key result
The crude aqueous extract of Carissa edulis significantly reduced mean arterial pressure from 137.00 ± 8.01 mmHg to 94.75 ± 2.84 mmHg in L-NAME induced hypertensive rats.
Why the study?
Conventional hypertension management is costly and causes side effects, prompting interest in traditional medicinal plants such as Carissa edulis.
Does Carissa edulis extract reduce blood pressure in L-NAME-induced hypertensive Wistar rats?
Does Carissa edulis extract reduce blood pressure in L-NAME-induced hypertensive Wistar rats?
Absolute Event Rate: 94.75% vs 137%
p-value: p=<0.01
Crude aqueous extract and the aqueous fraction of Carissa edulis significantly reduce blood pressure in L-NAME-induced hypertensive rats, supporting its traditional use.
Should not inform clinical hypertension care; leaves open further preclinical development of Carissa edulis extracts.
High blood pressure is an important health problem because of its prevalence and its several complications. The high cost of its management and the side effects of conventional drugs have led patients to use medicinal plants. Carissa edulis is one of the plants used in the traditional management of hypertension. The aim of this study was to determine the effects of crude extract and fractions of Carissa edulis in L-NAME hypertension rats models. The phytochemical analysis of the extracts was carried out by using the thin layer chromatography method. The pharmacological effect was evaluated in Wistar rats rendered hypertensive by administering the N (ω) -Nitro-L-Arginine-Methyl Ester (L-NAME). The crude extract was administered at 500 mg / kg (b/w) and the fractions at 20 mg / kg (b/w). Blood pressure was measured by a non-invasive method. Four fractions were obtained after fractionation. Many chemical compounds were detected diversely distributed in either in the crude extract or in the fractions. The crude aqueous extract induced a significant decrease in blood pressure from 137, 00 ± 8,01 mmHg to 94,75 ± 2.84 mmHg. In the other hand, only the aqueous fraction exerted the highest effects by reducing the blood pressure from 137,00 ± 8,01 mmHg to 93,5±8,54 mmHg.
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Adjagba et al. (2022) studied L-NAME induced hypertension (n=50). Carissa edulis crude aqueous extract vs. L-NAME (distilled water) was evaluated on Mean arterial pressure (p=<0.01). The crude aqueous extract of Carissa edulis significantly reduced mean arterial pressure from 137.00 ± 8.01 mmHg to 94.75 ± 2.84 mmHg in L-NAME induced hypertensive rats.
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