Key result
Serum Tenascin-C levels accurately predicted left ventricular remodeling after acute myocardial infarction (AUC 0.872), with significantly higher levels in the remodeling group (80.3 vs 47.6 ng/ml, p=0.002).
Why the study?
Tenascin-C transiently appears during pathological conditions and plays important roles in tissue remodeling, prompting investigation into its clinical implications in AMI treated with thrombolytic therapy.
Do serum Tenascin-C levels predict left ventricular remodeling and MACE in patients with acute STEMI treated with thrombolytic therapy?
Observational (n=80)
Do serum Tenascin-C levels predict left ventricular remodeling and MACE in patients with acute STEMI treated with thrombolytic therapy?
Effect estimate: AUC 0.872
p-value: p=0.002
Serum Tenascin-C levels measured on admission can effectively predict left ventricular remodeling and major adverse cardiac events in patients with acute STEMI treated with thrombolytic therapy.
Objectives: We investigated clinical implications of serum Tenascin-C (TN-C) levels in patients with acute myocardial infarction (AMI) treated with thrombolytic therapy. Background: TN-C, an extracellular matrix glycoprotein, is not normally expressed in the adult heart, but transiently appears during pathological conditions and plays important roles in tissue remodeling. Methods: Serum TN-C levels were measured by ELISA in 60 cases presented with acute STEMI and 20 apparently healthy controls. Results: The mean serum TN-C level of AMI patients on admission was significantly higher than that of controls (57.5±19.9 ng/ml vs. 34.1±3.2 ng/ml; p> 0.0001), Follow-up examination (mean: 6 months) revealed that 17 of 60 AMI (28%) patients showed left ventricular (LV) remodeling (≥20% end-diastolic volume increase), and in 6 (10%), major adverse cardiac events (MACE) were detected. TN-C levels were significantly higher in remodeling versus non-remodeling group (80.3±19.9 vs 47.6±9.5 ng/ml p=0.002). By receiver-operating characteristic (ROC) analysis, clearly discriminated prediction of LV remodeling compared with other variables. Best predictive values of TN-C for remodeling were 68.9 ng/ml (81% sensitivity and 95% specificity, AUC=0.872). High serum TN-C level and DM were correlated with higher incidence of MACE. Conclusions: The findings suggest that serum TN-C levels might be useful in predicting LV remodeling and prognosis after AMI.
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Abdelrhman et al. (2019) conducted an observational in Acute myocardial infarction (n=80). Serum Tenascin-C (TN-C) levels vs. Non-remodeling group was evaluated on Left ventricular (LV) remodeling (≥20% end-diastolic volume increase) (AUC 0.872, p=0.002). Serum Tenascin-C levels accurately predicted left ventricular remodeling after acute myocardial infarction (AUC 0.872), with significantly higher levels in the remodeling group (80.3 vs 47.6 ng/ml, p=0.002).
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