What question did this study set out to answer?

To investigate serum tenascin-C levels in patients with acute myocardial infarction and assess its capacity to predict subsequent heart failure.

October 21, 2015Alexandria Journal of MedicineOpen Access

Value of serum tenascin-C in patients with acute myocardial infarction

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Why the study?

Are serum tenascin-C levels elevated in patients with acute myocardial infarction and do they correlate with the development of heart failure?

Population

45 individuals, comprising 15 patients with acute myocardial infarction, 15 patients with heart failure on…

Comparison

Measurement of serum tenascin-C levels on the… vs Healthy volunteers and patients with AMI without…

Design

Cross-sectional

Authors

RGRania GaberNahda University WIWesam IbrahimTanta University HNHanaa NofalTanta University

Discussion

Member takes

Implication

May support TN-C as post-MI remodeling marker; leaves open clinical utility pending prospective validation.

Key Points

To investigate serum tenascin-C levels in patients with acute myocardial infarction and assess its capacity to predict subsequent heart failure.
Conducted a matched study of 45 participants divided into three groups of 15: acute myocardial infarction alone, acute myocardial infarction complicated by heart failure, and healthy control volunteers.
Collected venous blood on the day of hospital admission and quantified serum tenascin-C levels via ELISA alongside cardiac enzymes (CK, CK-MB), troponin T, and pro-BNP.
Serum tenascin-C levels were significantly higher in patients with acute myocardial infarction and those with concurrent heart failure than in healthy volunteers.
Tenascin-C levels correlated positively with CK, CK-MB, and troponin T in acute infarction, as well as with pro-BNP in patients with heart failure on top of infarction.

Structured PICO

Are serum tenascin-C levels elevated in patients with acute myocardial infarction and do they correlate with the development of heart failure?

Population

45 individuals, comprising 15 patients with acute myocardial infarction (AMI), 15 patients with heart failure (HF) on top of MI, and 15 healthy volunteers, closely matched in age and sex.

Intervention

Measurement of serum tenascin-C (TN-C) levels on the day of admission

Comparator

Healthy volunteers and patients with AMI without heart failure

Outcome

Serum TN-C levels and their correlation with cardiac biomarkers (CK, CK-MB, troponin T, Pro-BNP) and heart failure statussurrogate

Serum tenascin-C is elevated in acute myocardial infarction and correlates with established cardiac biomarkers and heart failure, suggesting potential utility in risk stratification for post-MI remodeling.

Limitations

small sample size

Cite This Study

Gaber et al. (2015) studied this question.

synapsesocial.com/papers/6a7146ddc92390ac2d07ed5e https://doi.org/10.1016/j.ajme.2015.09.003

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Value of serum tenascin-C in patients with acute myocardial infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Value of serum tenascin-C in patients with acute myocardial infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider