What does this research mean for the field?

Tenascin-C expression in endomyocardial biopsies correlates with the severity of histological lesions and accurately reflects active-stage inflammation in human acute myocarditis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the expression of tenascin-C in myocardial tissue from myocarditis patients and assess its diagnostic utility for determining inflammatory activity in biopsy specimens.

February 1, 2005The Journal of Pathology

Diagnostic utility of tenascin‐C for evaluation of the activity of human acute myocarditis

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Why the study?

Does immunostaining for Tenascin-C reflect inflammatory activity in endomyocardial biopsy specimens from patients with acute myocarditis?

Population

32 patients with a clinical diagnosis of acute myocarditis

Comparison

Immunostaining and in situ hybridization for… vs Histological diagnosis according to the Dallas…

Design

Cohort

Follow-up

during convalescence

Authors

SMS MorimotoFujita Health University KIKyoko Imanaka‐YoshidaHeart Failure & Transplant SHShinya HiramitsuNagoya Heart Center

Discussion

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Implication

May aid biopsy detection of active myocarditis; leaves open diagnostic utility pending prospective validation.

Key Points

To evaluate the expression of tenascin-C in myocardial tissue from myocarditis patients and assess its diagnostic utility for determining inflammatory activity in biopsy specimens.
Examined 113 endomyocardial biopsy specimens from 32 patients clinically diagnosed with acute myocarditis using immunohistochemistry and in situ hybridization for tenascin-C.
Semi-quantified tenascin-C immunostaining and compared the findings against histological grading according to the Dallas criteria, including serial convalescent biopsies from 22 patients.
Tenascin-C expression was specifically detected in biopsy specimens during active-stage inflammation and disappeared during healed stages.
The degree of tenascin-C expression strongly correlated with the severity of histological inflammatory lesions.

Structured PICO

Does immunostaining for Tenascin-C reflect inflammatory activity in endomyocardial biopsy specimens from patients with acute myocarditis?

Population

32 patients with a clinical diagnosis of acute myocarditis (yielding 113 biopsy specimens, with serial biopsies from 22 patients during convalescence)

Intervention

Immunostaining and in situ hybridization for Tenascin-C (TN-C) on endomyocardial biopsy specimens

Comparator

Histological diagnosis according to the Dallas criteria

Outcome

Correlation of TN-C expression degree with the severity of histological lesions and inflammatory activitysurrogate

Immunostaining for Tenascin-C in endomyocardial biopsies correlates with histological severity and may enhance the diagnostic sensitivity for active human acute myocarditis.

Cite This Study

Morimoto et al. (2005) studied this question.

synapsesocial.com/papers/6a1bd2fdd54006be995f0fa7 https://doi.org/10.1002/path.1730

Topics

Myocarditis

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Diagnostic utility of tenascin‐C for evaluation of the activity of human acute myocarditis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Diagnostic utility of tenascin‐C for evaluation of the activity of human acute myocarditis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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