Key result
Tenascin-C expression was upregulated at a very early stage of myocarditis in mouse models, correlating with histological evidence of inflammatory activity.
Why the study?
Does Tenascin-C expression correlate with disease activity in myosin-induced autoimmune myocarditis mouse models?
Population
Myosin-induced autoimmune myocarditis mouse models
Design
Preclinical
Authors
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May support Tenascin-C as early biomarker in preclinical myocarditis; leaves open human validation and clinical utility.
Does Tenascin-C expression correlate with disease activity in myosin-induced autoimmune myocarditis mouse models?
Tenascin-C is a useful early biomarker for evaluating disease activity and inflammation in myocarditis.
Hiroe et al. (2002) studied Myocarditis. Tenascin-C expression was evaluated on Expression of Tenascin-C (amount, localization, and producing cells). Tenascin-C expression was upregulated at a very early stage of myocarditis in mouse models, correlating with histological evidence of inflammatory activity.
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