Key result
Higher BMI at kidney transplant predicted increased 5-year cardiac risk, with each 5-unit BMI increase raising the adjusted risk of a cardiac composite by 19% (HR 1.19; 95% CI 1.00-1.43; P=0.049).
Why the study?
Does higher BMI at transplant increase posttransplant cardiac risk in renal allograft recipients?
Cohort (n=1,102)
No
Does higher BMI at transplant increase posttransplant cardiac risk in renal allograft recipients?
Hazard Ratio: 1.19 (95% CI 1–1.43)
Absolute Event Rate: 29.35% vs 8.67%
p-value: p=0.049
Higher BMI at the time of kidney transplantation is an independent predictor of increased posttransplant cardiac risk, particularly for heart failure and atrial fibrillation.
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May warrant closer cardiac monitoring in obese kidney recipients; leaves open whether pretransplant weight loss reduces events.
Lentine et al. (2008) conducted a cohort in Kidney transplantation (n=1,102). High body mass index (BMI) vs. Low BMI was evaluated on Composite of congestive heart failure, atrial fibrillation, and myocardial infarction (adjusted HR 1.19, 95% CI 1.00-1.43, p=0.049). Higher BMI at kidney transplant predicted increased 5-year cardiac risk, with each 5-unit BMI increase raising the adjusted risk of a cardiac composite by 19% (HR 1.19; 95% CI 1.00-1.43; P=0.049).
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