Study on Enhancement of Osseointegration of the Bio-Active Titanium Implant by Low Intensive Ultrasound WaveFull Text

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In present study, the effect of the ultrasound wave stimulation in acceleration of the osteocondutibity of bioactive pure titanium was investigated. Pure titanium (99.9% Ti) processed in chemical and heat treatments was used as a specimen, and soaked in simulated body fluid (SBF) under pulsed ultrasound wave for the planned time periods. The surface of samples was observed using scanning electron microscopy (SEM), Xray diffraction, etc, to assess the state of hydroxyapatite formation.SEM images showed that a richer and finer layer of calcium and phosphate compounds covered the titanium surface in the ultrasound wave group as compared with the non-ultrasound group. The measurements of mass of specimens also indicated the efficiency of ultrasound waves for hydroxyapatite formation. These findings suggest that the nucleation and crystallization of apatite on bio-active material surfaces might be promoted by micro-moving and cavitation of low-intensity pulsed ultrasound waves. We propose that pulsed ultrasound stimulation has a great potential for further improvement of osteointegration and osteoconductivity for medical bio-active implants.