Key result
Among 41 published cases of triple-valve endocarditis, surgical intervention occurred in 65.9% of cases, with Streptococcus spp being the most common organism and 10 in-hospital deaths reported.
Why the study?
Triple-valve endocarditis is a rare phenomenon that presents a unique management challenge given the paucity of summative analyses.
Systematic Review (n=41)
Triple-valve endocarditis is a rare condition most commonly caused by Streptococcus species, frequently requiring surgical valve replacement or repair, and carrying a notable risk of in-hospital mortality.
May inform early TVE recognition in bacteremic patients; leaves open prospective data on management.
Multivalve endocarditis with triple valve involvement is a rare phenomenon and presents a unique management challenge to physicians given the paucity of summative analyses. Google Scholar and PubMed databases were searched for terms related to triple-valve endocarditis (TVE). Articles published up until December 31, 2023, were included. We identified 41 published cases of triple-valve endocarditis. The most common source of infection was dental/oral (n = 10). Streptococcus spp was the most common organism isolated (n = 15), followed by Staphylococcus organisms (n = 9). Surgical intervention occurred in 65.9% (n = 27) of cases, and the most common surgery was valve replacement (n = 24) followed by valve repair (n = 10). Endocarditis complications included valvular insufficiency (n = 33) and heart failure (n = 15). Most patients were discharged from the hospital (n = 26), but there were 10 in-hospital deaths and 4 discharged to hospice care.
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Peterson et al. (2025) conducted a systematic review in Triple-valve endocarditis (n=41). Triple-valve endocarditis was evaluated on Surgical intervention, complications, and mortality. Among 41 published cases of triple-valve endocarditis, surgical intervention occurred in 65.9% of cases, with Streptococcus spp being the most common organism and 10 in-hospital deaths reported.
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