Key result
Medical therapy resolves biventricular thrombi and restores LVEF to 53% in severe cardiomyopathy.
Why the study?
Biventricular thrombi is a rare condition with high morbidity and mortality, and limited research exists on optimal management strategies.
Case Report (n=1)
Conservative medical management with antimicrobials and anticoagulation can lead to successful resolution of biventricular thrombi and tricuspid valve infective endocarditis in select patients with dilated cardiomyopathy.
May support medical management in select IE cases with biventricular thrombi; hypothesis-generating and requires prospective validation.
Background: Biventricular thrombi (BVT) is a rare presentation associated with high morbidity and mortality due to the potential sequela of life-threatening complications including embolic events and cardiac failure. As an uncommon entity, there is limited research on best practice for the management of BVT. Presentation: concomitant bloodstream infection, tricuspid valve infective endocarditis (TVIE), septic emboli and decompensated dilated cardiomyopathy (LVEF 20%-25%). Guideline directed heart failure management, antimicrobials and anticoagulation were initiated with a remarkable recovery within 2 months. Discussion: Given the rarity of this presentation, a multidisciplinary approach was taken to guide management. Follow-up echocardiography after completion of antimicrobial therapy demonstrated an LVEF of 53%, no detectable thrombus and resolution of congestive symptoms. Although there is minimal population-based evidence, this case supports a conservative approach for the treatment of TVIE, BVT and its potential sequelae in select patients.
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Phipps et al. (2026) conducted a case report in Tricuspid valve infective endocarditis with biventricular thrombi (n=1). Medical management (antimicrobials, anticoagulation, and heart failure therapy) was evaluated on Clinical recovery and thrombus resolution. Conservative medical management with antimicrobials, anticoagulation, and heart failure therapy led to complete resolution of biventricular thrombi and improvement of LVEF to 53%.
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