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Experiments in the 1950s showed that haemopoiesis could be restored in irradiated animals by engraftment of transfused marrow.Attempts to translate this into clinical practice were hindered by immunological problems of transfer between individuals which we now recognise as rejection and graft versus host disease.With further understanding of the human leucocyte antigen system, rapid clinical progress was made during the 1970s such that bone marrow transplantation soon became an established treatment for some immune deficiency and malignant diseases.
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Andrew Duncombe (1997) studied this question.
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