Key result
The highest tertile of sE-selectin was associated with a significantly higher prevalence of heterogeneous carotid plaque compared to the lowest tertile (OR 2.2) in Japanese men.
Why the study?
Are higher levels of soluble E-selectin and hs-CRP associated with increased carotid intima-media thickness in older Japanese men?
Cross-Sectional (n=505)
No
Are higher levels of soluble E-selectin and hs-CRP associated with increased carotid intima-media thickness in older Japanese men?
Odds Ratio: 2.2 (95% CI 1–3.7)
p-value: p=0.002
Higher serum levels of soluble E-selectin and hs-CRP are associated with increased carotid intima-media thickness and heterogeneous plaque prevalence in older Japanese men.
Should not yet change plaque risk assessment; hypothesis-generating for sE-selectin in carotid studies.
AIM: E-selectin and C-reactive protein have been linked with carotid atherosclerosis; however, the findings on this association have been inconsistent. METHODS AND RESULTS: We conducted a cross-sectional study to examine the associations of soluble E-selectin (sE-selectin) and high-sensitivity-CRP (hs-CRP) levels with carotid intima-media thickness (IMT) in 505 Japanese men aged 60-74 years. Maximum IMT of common (CCA) and internal carotid arteries (ICA) was positively associated with sE-selectin levels after adjustment for age, hs-CRP and other cardiovascular risk factors: means of maximum CCA IMT were 1.12, 1.21 and 1.27 mm for the lowest to highest tertiles of sE-selectin, respectively, p=0.04, and those of ICA IMT were 1.73, 2.09 and 2.09 mm, respectively, p=0.009. Maximum IMT of CCA tended to be positively associated hs-CRP levels after adjustment for age, sE-selectin and other cardiovascular risk factors: means of maximum CCA IMT were 1.10, 1.25, and 1.26 mm, for the lowest to highest tertiles of hs-CRP, respectively, p=0.06. Compared with subjects with the lowest tertiles of sE-selectin and hs-CRP, those with the highest tertiles had a higher prevalence of heterogeneous plaque: multivariable odds ratios were 2.2 (1.03.7), p=0.002 and 1.6 (1.02.7), p=0.046, respectively. CONCLUSIONS: Serum levels of sE-selectin and hs-CRP could be biomarkers for atherosclerosis in general populations.
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Sakurai et al. (2009) conducted a cross-sectional in Asymptomatic carotid atherosclerosis (n=505). Highest tertile of sE-selectin vs. Lowest tertile of sE-selectin was evaluated on Prevalence of heterogeneous carotid plaque (OR 2.2, 95% CI 1.0-3.7, p=0.002). The highest tertile of sE-selectin was associated with a significantly higher prevalence of heterogeneous carotid plaque compared to the lowest tertile (OR 2.2) in Japanese men.
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