Chemical biology study reveals a selective bicyclic hydantoin probe for glyceraldehyde 3-phosphate dehydrogenases, indicating utility for monitoring enzyme changes during plant infections.
Exceptionally specific: The natural-product-like structural complexity of a bicyclic hydantoin was exploited to generate the novel, highly specific activity-based profiling probe (ABPP) Mrl-Rh (Rh=rhodamine; see picture) for glyceraldehyde 3-phosphate dehydrogenases. This probe can be used to investigate activity changes of this enzyme class during plant–pathogen interactions.
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Kaschani et al. (2012) studied this question.
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