Key result
Regional myocardial blood flow assessed by exponential infusion of 11C-Butanol correlated closely with values obtained with radiolabeled microspheres (r = 0.986).
Why the study?
Does intravenous administration of 11C-Butanol at an exponentially increasing rate accurately quantify regional myocardial perfusion compared to radiolabeled microspheres in open chest dogs?
Does intravenous administration of 11C-Butanol at an exponentially increasing rate accurately quantify regional myocardial perfusion compared to radiolabeled microspheres in open chest dogs?
Exponential infusion of 11C-Butanol accurately quantifies regional myocardial perfusion in a canine model, demonstrating potential for future use in positron emission tomography.
Supports preclinical PET perfusion quantification; leaves open human translation.
This study was designed to determine whether regional myocardial perfusion can be assessed quantitatively in vivo in dogs by administration of a freely diffusible tracer intravenously at an exponentially increasing-rate. Previously, we reported the mathematical basis of the approach and its use for assessment of global perfusion in isolated hearts. In this study, computer simulations demonstrated that inter-regional diffusion of tracer perturbs results by no more than 7 percent under worst case conditions. Regional myocardial blood flow assessed in open chest dogs with myocardial activity deternined by well counting by the exponential infusion method correlated closely to values obtained with radiolabeled microspheres (r = 0.986, n = 35 determinations). Thus, regional myocardial perfusion can be quantified with an infusion technique potentially applicable to the tomographic characterization of impaired perfusion in experimental animals and ultimately in patients with positron emission tomography.
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Hack et al. (1983) studied Regional myocardial perfusion (n=35). Exponential infusion of 11C-Butanol vs. Radiolabeled microspheres was evaluated on Regional myocardial blood flow correlation (r = 0.986). Regional myocardial blood flow assessed by exponential infusion of 11C-Butanol correlated closely with values obtained with radiolabeled microspheres (r = 0.986).
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