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Neurofunk: Highlights of the synthesis of 1, a potent modulator of neurotrophic factors, include construction of the B ring through an asymmetric Robinson annulation, assembly of the E ring lactone through a novel acid-induced cascade reaction, and Pd0-mediated carbomethoxylation and methylation reactions for the construction of the C and A rings, respectively.
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Xu et al. (2011) studied this question.
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