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May 17, 2021BMC Infectious DiseasesOpen Access

Genetic diversity of Coxsackievirus A21 associated with sporadic cases of acute respiratory infections in Malaysia

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Key result

Epidemiological surveillance of 3,935 patients with acute respiratory infections in Malaysia revealed a low-level detection of Coxsackievirus A21 at 0.08% (1.4 cases/year).

Why the study?

Coxsackievirus A21 has been associated with respiratory illnesses in humans, prompting investigation into its molecular epidemiology.

Population

3935 patients presenting with acute upper respiratory illnesses in ambulatory settings in Kuala Lumpur, Malaysia

Design

Molecular epidemiological investigation

Authors

NSNur Izzati SupianKNKim Tien NgAgency for Science, Technology and ResearchJCJack Bee ChookSunway University

Discussion

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Overview

May indicate limited endemic presence in Malaysia; extends surveillance data but leaves open questions on clinical significance.

Study Design

Type

Observational (n=3,935)

Multicenter

No

Structured PICO

P
Population
3,935 outpatients presenting with acute respiratory tract infections at a primary care clinic in Kuala Lumpur, Malaysia, screened between 2012 and 2014.
O
Outcome
Detection rate and genetic diversity/phylogenetic characteristics of Coxsackievirus A21 (CVA21)

The study highlights the emerging role of CVA21 in causing sporadic acute respiratory outbreaks and maps its global genetic diversity.

Limitations

  • Relatively old sampling period
  • Limited sampling site
  • Inability to establish the seasonality of CVA21 due to the low detection rate
  • relatively old sampling period
  • limited sampling site
  • inability to establish the seasonality of CVA21 due to the low detection rate

Cite This Study

Supian et al. (2021) conducted an observational in Acute respiratory tract infections (n=3,935). Coxsackievirus A21 (CVA21) infection was evaluated on Detection rate of CVA21. Epidemiological surveillance of 3,935 patients with acute respiratory infections in Malaysia revealed a low-level detection of Coxsackievirus A21 at 0.08% (1.4 cases/year).

synapsesocial.com/papers/6a954eb27007bd2ef4e3c849https://doi.org/10.1186/s12879-021-06148-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Complete Nucleotide Sequence of Coxsackievirus A211989 · 102 citations
  2. 2Coxsackievirus A21, Enterovirus 68, and Acute Respiratory Tract Infection, China2012 · 80 citations
  3. 3Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007‐20132019 · 16 citations
  4. 4Adenovirus type 4 respiratory infections with a concurrent outbreak of coxsackievirus A21 among United States Army Basic Trainees, a retrospective viral etiology study using next‐generation sequencing2017 · 25 citations
  5. 5MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms2018 · 39,636 citations