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January 13, 1962JAMA

Acute Respiratory Disease Associated with Coxsackie A-21 Virus Infection

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Key result

Neutralizing antibodies linked to protection against Coxsackie A-21 infection and mild respiratory disease.

Population

Military personnel at a large military base during an outbreak of Coxsackie A-21 virus infection

Design

Cohort

Authors

KJKarl M. JohnsonUniversity of New Mexico

Discussion

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Overview

May inform surveillance in closed populations; leaves open generalizability and interventional studies.

Study Design

Type

Observational

Structured PICO

P
Population
Military personnel at a large military base (including distinct recruit and 'seasoned' groups) during an outbreak of Coxsackie A-21 virus infection
O
Outcome
Illness associated with infection (mild undifferentiated respiratory disease) and virus detection

Coxsackie A-21 virus infection in a military base caused mild respiratory disease, with neutralizing antibodies providing protection and non-immune factors influencing spread.

Cite This Study

Karl M. Johnson (1962) conducted an observational in Coxsackie A-21 virus infection. Coxsackie A-21 virus infection was evaluated on Infection and associated illness. Coxsackie A-21 virus infection in a military base outbreak was associated with mild respiratory disease, with neutralizing antibodies conferring protection against infection and illness.

synapsesocial.com/papers/6aa103d29318be7e6b997d47https://doi.org/10.1001/jama.1962.03050020006002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute Respiratory Disease Associated With Coxsackie A-21 Virus Infection1962 · 41 citations
  2. 2Immunologic Identification of Coxsackie A21 Virus with Coe Virus.1961 · 15 citations
  3. 3Genetic diversity of Coxsackievirus A21 associated with sporadic cases of acute respiratory infections in Malaysia2021 · 6 citations
  4. 4Response of Volunteers to Inoculation with Hemagglutinin-positive and Hemagglutinin-negative Variants of Coxsackie A21 Virus*1965 · 6 citations
  5. 5An outbreak of Coxsackievirus A6 infection in adults of a collective unit, China, 20192019