Key result
Preexisting Coxsackie B4 antibodies fail to prevent respiratory illness despite ~67% lower reinfection rates.
Why the study?
An outbreak of respiratory illness associated with Coxsackie B4 virus in children was observed, but the clinical spectrum and role of preexisting antibodies were not fully characterized.
Population
Children in a children's home during a summer 1964 outbreak
Comparison
Children with and without preexisting Coxsackie B4 antibodies
Design
Observational outbreak analysis
Follow-up
3 to 7 days
Authors
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Preexisting antibodies may not protect children from Coxsackie B4 respiratory infection; leaves open questions on humoral immunity and reinfection risk.
Observational
No
Absolute Event Rate: 33.3% vs 100%
Coxsackie B4 virus can cause mild respiratory illness in children, with a high rate of subclinical infections and reinfections even in the presence of preexisting antibodies.
Ray et al. (1967) conducted an observational in Acute respiratory illness associated with Coxsackie B4 virus. Preexisting Coxsackie B4 antibodies (≥1:8 titer) vs. No preexisting antibodies (<1:8 titer) was evaluated on Serological evidence of infection or reinfection following the outbreak. Preexisting Coxsackie B4 antibodies did not prevent respiratory illness, with 33% of seropositive and 100% of seronegative children showing serological evidence of infection during an outbreak.
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