Key result
Idiopathic scoliosis in female subjects was characterized by marked osteoporosis in approximately half of the cohort compared to normal subjects, despite BMD increases over 30.8 months.
Observational (n=22)
Female subjects with idiopathic scoliosis exhibit persistent osteoporosis compared to normal subjects, despite some increases in bone mineral density over time.
Persistent osteoporosis in half of females with idiopathic scoliosis may warrant monitoring; leaves open causal role in progression.
A follow-up study of the bone mineral densities (BMD) of 22 female subjects with idiopathic scoliosis was performed using dual-photon absorptiometry at an average follow-up period of 30.8 months. Compared to the initial scans, statistically significant increases in lumbar spine and femoral neck BMD were observed. When compared to normal subjects, approximately half of the scoliotic subjects were markedly osteoporotic, having BMD measurements at least two standard deviations below the expected value. Scoliotic curvature data could not be correlated with the BMD data. The observed osteoporosis is not transient and appears characteristic of idiopathic scoliosis.
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Thomas et al. (1992) conducted an observational in Idiopathic scoliosis (n=22). Idiopathic scoliosis vs. Normal subjects was evaluated on Lumbar spine and femoral neck bone mineral density (BMD). Idiopathic scoliosis in female subjects was characterized by marked osteoporosis in approximately half of the cohort compared to normal subjects, despite BMD increases over 30.8 months.
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