Key result
Women with polycystic ovary syndrome had significantly higher follicular fluid concentrations of tumor necrosis factor-α and increased obesity indices compared to women without the condition.
Why the study?
Polycystic ovary syndrome is considered a proinflammatory endocrine disorder, and obesity may play a role in initiating or exacerbating inflammation in the follicular fluid of affected patients.
Cross-Sectional (n=40)
No
Answers are grounded in this paper and cite their sources.
Obesity and pro-inflammatory markers like TNF-α are significantly elevated in the follicular fluid of women with PCOS, suggesting a role for inflammation in the pathogenesis of the syndrome.
Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder and is considered a proinflammatory disease.Obesity is also a common pro-inflammatory phenotype in PCOS patients, which may play a role in the initiation or exacerbation of inflammation in PCOS patients.In this study, the role of various obesity indicators in increasing inflammation in the follicular fluid of PCOS patients has been investigated.Materials and methods: 40 patients under 35 years were divided into two groups: PCOS and non-PCOS.Different obesity indices (body mass, neck circumference, arm circumference, and waist to hip circumference) were measured in each patient.Follicular fluid samples were collected from each patient.The concentration of tumor necrosis factor-α (TNF-α) in follicular fluid samples of patients was quantitatively evaluated using the ELISA method.The number of cumulus-oocyte complexes (COC) was recovered and their quality was scored.Results: In the PCOS group, various obesity indices were significantly increased compared to the non-PCOS group (P ≤0.001).The concentration of TNF-α in the PCOS group was significantly higher than the other group (P<0.001).There were no significant differences in the number of retrieved COC per patient and the quality of oocytes between the groups (P>0.05). Conclusion:Considering the important role of inflammation in the development of PCOS disease, management of obesity in PCOS patients may help to reduce inflammation and can potentially help to design personalized therapeutic approaches.
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Shirvanizadeh et al. (2024) conducted a cross-sectional in Polycystic ovary syndrome (n=40). Polycystic ovary syndrome (PCOS) vs. Non-PCOS was evaluated on Concentration of tumor necrosis factor-α (TNF-α) in follicular fluid (p=<0.001). Women with polycystic ovary syndrome had significantly higher follicular fluid concentrations of tumor necrosis factor-α and increased obesity indices compared to women without the condition.
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