Review analyzes inflammatory profiles in PCOS and obesity, suggesting implications for clinical management.
Polycystic ovary syndrome (PCOS) exacerbated by obesity represents a complex intersection of endocrine and immune dysregulation, significantly impairing reproductive and metabolic health. This characterizes the immune-inflammatory landscape of the phenotype and evaluate the clinical utility of the Systemic Immune-Inflammation Index (SII) in assessing inflammatory status and predicting long-term complications. Furthermore, analyze how systemic chronic inflammation alters the ovarian microenvironment-specifically impairing follicular development, granulosa cell function, and oocyte quality-through the recruitment of macrophages, T-cell activation, and the elevation of pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). Finally, focused on emerging diagnostic and therapeutic strategies centered on immunomodulation, offering a framework for precision clinical management.
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Li et al. (2026) studied this question.
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