Key result
The volume output of blood per minute from the failing heart is diminished and its size is larger than when in a state of compensation.
Observational
Answers are grounded in this paper and cite their sources.
Early physiological observation demonstrating that cardiac output is diminished and heart size is increased during uncompensated heart failure.
Article1 June 1940THE CARDIAC OUTPUT IN CONGESTIVE HEART FAILURE AND IN ORGANIC HEART DISEASEHAROLD J. STEWART, M.D., F.A.C.P., NORMAN F. CRANE, M.D., ROBERT F. WATSON, M.D., CHARLES H. WHEELER, M.D., JOHN E. DEITRICK, M.D.HAROLD J. STEWART, M.D., F.A.C.P.Search for more papers by this author, NORMAN F. CRANE, M.D.Search for more papers by this author, ROBERT F. WATSON, M.D.Search for more papers by this author, CHARLES H. WHEELER, M.D.Search for more papers by this author, JOHN E. DEITRICK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-12-2323 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe mechanism of heart failure is still the subject of investigation. In recent years, however, observations have been made which lead to a clearer understanding of its pathological physiology. In 1932 Stewart and Cohn1published data showing that in human beings "The volume output of blood per minute from the heart which is in failure is diminished and its size larger than when it is in a state of compensation." In addition, there were certain observations relating to dogs pointing to the same conclusions.2Since then Stewart and his associates3have made further investigations of patients suffering from congestive heart...Bibliography1. STEWARTCOHN HJAE: Studies on the effect of the action of digitalis on the output of blood from the heart. III. The effect on the output of hearts in heart failure with congestion, in human beings, Jr. Clin. Invest., 1932, xi, 917-955. CrossrefGoogle Scholar2. STEWARTCOHN HJAE: Studies of the effect of the action of digitalis on the output of blood from the heart. II. The effect on the output of the hearts of dogs subject to artificial auricular fibrillation, Jr. Clin. Invest., 1932, xi, 897-916. CrossrefGoogle Scholar3. 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Heart Jr., 1938, xvi, 477-500. CrossrefGoogle Scholar15. MCGUIRESHOREHAUENSTEINGOLDMAN JRVF: Relation of cardiac output to congestive heart failure, Arch. Int. Med., 1939, lxiii, 290-297. CrossrefGoogle Scholar16. MCGUIRESHOREHAUENSTEINGOLDMAN JRVF: The cardiac output in compensation and decompensation in the same individual, Am. Heart Jr., 1938, xvi, 449-461. CrossrefGoogle Scholar17. HARRISONFRIEDMANCLARKRESNIK TRBGH: The cardiac output in relation to cardiac failure, Arch. Int. Med., 1934, liv, 239-255. CrossrefGoogle Scholar18. ALTSCHULE MD: The pathological physiology of chronic cardiac decompensation, Medicine, 1938, xvii, 75-154. CrossrefGoogle Scholar19. STARLING EH: The Linacre Lecture on the Law of the Heart, Given at Cambridge, 1915; 1918, Longmans, Green and Co., London. Google Scholar20. STARRDONALMARGOLIESSHAWCOLLINSGAMBLE IJSARLHCJ: Studies of the heart and circulation in disease: Estimations of basal cardiac output, metabolism, heart size, and blood pressure in two hundred and thirty-five subjects, Jr. Clin. Invest., 1934, xiii, 561-592. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication October 3, 1939.Read in part at the New York Meeting of the American College of Physicians April 6, 1938.From the Department of Medicine of the New York Hospital and Cornell University Medical College, New York, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRenal hemodynamics in heart diseaseCardiac output in heart failure 1 June 1940Volume 13, Issue 12Page: 2323-2340KeywordsBlood volumeCardiac outputCardiovascular therapyHeartHeart failureHospital medicine ePublished: 1 December 2008 Issue Published: 1 June 1940 PDF downloadLoading ...
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Stewart et al. (1940) conducted an observational in Congestive heart failure and organic heart disease. Congestive heart failure vs. Compensated state was evaluated on Cardiac output and heart size. The volume output of blood per minute from the failing heart is diminished and its size is larger than when in a state of compensation.
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