Key result
Cyclophosphamide converted mild Sendai virus infection in mice into a serious and sometimes fatal pneumonic illness due to failure of viral clearance.
Why the study?
Does cyclophosphamide worsen Sendai virus infection in mice?
Population
Mice infected with Sendai virus
Comparison
Cyclophosphamide vs Untreated infected mice (implied)
Design
Preclinical
Authors
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May heighten severe pneumonia risk with cyclophosphamide during viral infections; leaves open human translation from this murine model.
Does cyclophosphamide worsen Sendai virus infection in mice?
Cyclophosphamide exacerbates Sendai virus infection in mice by impairing viral clearance and immune responses, highlighting potential respiratory disease risks during immunosuppressant therapy.
Robinson et al. (1969) studied Sendai virus infection. Cyclophosphamide was evaluated on Severity of pneumonic illness and viral clearance. Cyclophosphamide converted mild Sendai virus infection in mice into a serious and sometimes fatal pneumonic illness due to failure of viral clearance.
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