Key result
Heparin enhanced ADP-induced platelet aggregation during cardiopulmonary bypass surgery, an effect that was maintained throughout the procedure and reversed by protamine sulphate.
Why the study?
Does systemic heparinization enhance ADP-induced platelet aggregation in patients undergoing cardiopulmonary bypass surgery?
Observational
Does systemic heparinization enhance ADP-induced platelet aggregation in patients undergoing cardiopulmonary bypass surgery?
Heparin enhances ADP-induced platelet aggregation during cardiopulmonary bypass, which is reversed by protamine and may contribute to postoperative microembolization.
Answers are grounded in this paper and cite their sources.
Heparin may promote platelet hyperaggregability during CPB; this Level 3 finding leaves open its contribution to microembolization and needs prospective validation.
Heparin has been shown to enhance ADP-induced platelet aggregation in patients undergoing cardiopulmonary bypass surgery. This effect appears to be maximal throughout the initial 30 minutes of systemic heparinization and once reached is maintained throughout the bypass procedure. The prebypass state is regained following heparin reversal by protamine sulphate. It is possible that this effect of heparin on platelet function may contribute towards some of the platelet microembolization phenomena seen in patients following cardiopulmonary bypass surgery.
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Abela et al. (1986) conducted an observational in Cardiopulmonary bypass surgery. Heparin vs. Prebypass state was evaluated on ADP-induced platelet aggregation. Heparin enhanced ADP-induced platelet aggregation during cardiopulmonary bypass surgery, an effect that was maintained throughout the procedure and reversed by protamine sulphate.
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