Syntheses of 2-Hydroxymethyl-4(3H)-quinazoline and Its Analogs

The syntheses of 6-ethoxycarbonyl-2-hydroxymethyl-5.7dimethyl-413H)-quinazolinone.7-(or 6 -) -e t h o x y c a r b o n y l -2 .6 .8 -( o r 2,5,7-)-trimethyl-3-phenyl-4(3~l-guina~olinone were described.The 3-phenyl-4(3&)-quinazolinone compounds were further converted to the corresponding 2-hydroxymethyl derivative.The starting compounds, 2-amino-4-ethoxycarbonyl-3.5-dimethylbenzoicacid and 2-amino-5ethoxycarbonyl-4,6-dimethylbenzoic acid were prepared by the Hofmann reaction of the corresponding phthalimlde.