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April 7, 2001Organic Letters

Efficient Asymmetric Synthesis of α-Trifluoromethyl-Substituted Primary Amines via Nucleophilic 1,2-Addition to Trifluoroacetaldehyde SAMP− or RAMP−Hydrazone

Dieter Enders Kazumasa Funabiki

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Abstract

[reaction: see text] An efficient asymmetric synthesis of alpha-trifluoromethyl-substituted primary amines via nucleophilic 1,2-addition of alkyllithium reagents to trifluoroacetaldehyde SAMP- or RAMP-hydrazone followed by benzoylation and SmI(2)-promoted nitrogen-nitrogen single bond cleavage is described.

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Enders et al. (2001) studied this question.

synapsesocial.com/papers/6a955e2c3d7e4fca39b2e20e https://doi.org/10.1021/ol015869g

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Design of chiral derivatizing agents for the chromatographic resolution of optical isomers. Asymmetric synthesis of some chiral fluoroalkylated aminesOriginal Research · 1977 · 74 citations
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