Key result
A 19-month-old girl with a history of recurrent bronchiolitis died from a disseminated human rhinovirus C8 infection, with infectious virions successfully isolated from her blood.
Case Report (n=1)
No
This case report demonstrates that human rhinovirus C can cause authentic viremia and disseminated infection leading to fatal acute respiratory distress in children.
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May prompt consideration of disseminated HRV-C in fatal pediatric respiratory failure; leaves open prevalence and mechanisms.
We report a fatal case of acute lower respiratory tract disease with human rhinovirus C (HRV-C) as the unique cause in a 19-month-old girl with a history of repeated episodes of bronchiolitis. HRV-C type 8 nucleic acids were observed in respiratory, stool, and cerebrospinal fluid samples, and infectious virions were isolated from patient serum after inoculation onto reconstituted airway epithelia.
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Lupo et al. (2015) conducted a case report in Disseminated Rhinovirus C8 Infection (n=1). Human rhinovirus C8 infection was evaluated on Clinical outcome and viral isolation. A 19-month-old girl with a history of recurrent bronchiolitis died from a disseminated human rhinovirus C8 infection, with infectious virions successfully isolated from her blood.
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