Key result
The C-STRIDE study is a national cohort designed to enroll approximately 3,000 pre-dialysis CKD patients in China to investigate risk factors for CKD progression, cardiovascular events, and death.
Why the study?
What are the risk factors and underlying mechanisms of CKD progression and its association with adverse consequences in Chinese pre-dialysis CKD patients?
Cohort (n=3,000)
Yes
What are the risk factors and underlying mechanisms of CKD progression and its association with adverse consequences in Chinese pre-dialysis CKD patients?
The C-STRIDE study is a national cohort designed to provide evidence on the mechanisms of CKD progression and inform clinical guidelines and healthcare policies in China.
BACKGROUND: Chronic kidney disease (CKD) is a common disorder associated with multiple adverse clinical consequences, especially cardiovascular risk and end-stage renal disease. A recent national survey demonstrated that CKD has become a leading health problem in China. There is an urgent need to implement an in-depth investigation of the CKD burden and also to explore underlying mechanisms of CKD progression and it association with adverse consequences. METHODS: The Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) is the first national CKD cohort in China. It will enroll approximately 3 000 pre-dialysis CKD patients aged between 18 and 74 years and follow-up for at least 5 years. Questionnaires, anthropometric measures, laboratory tests, and biomaterials will be collected at baseline and annually. The principal clinical outcomes of the C-STRIDE consist of renal disease events, cardiovascular events, and death. Based on the longitudinal clinical data and biomaterials, the risk factors with CKD progression and other outcomes will be analyzed, and candidate markers and predicted models will be established. CONCLUSION: The C-STRIDE would provide important evidence for underlying mechanisms of CKD progression, valuable information for clinical guidelines, and healthcare policies in China.
No takes yet. Share an insight, caveat, or question.
Gao et al. (2014) conducted a cohort in Chronic kidney disease (n=3,000). Risk factors for CKD progression was evaluated on Renal disease events, cardiovascular events, and death. The C-STRIDE study is a national cohort designed to enroll approximately 3,000 pre-dialysis CKD patients in China to investigate risk factors for CKD progression, cardiovascular events, and death.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: