Key result
Following Marek's disease virus infection, splenocytes from susceptible chicken lines expressed high levels of IL-6 and IL-18 mRNA during the early cytolytic phase, whereas resistant lines expressed neither.
Population
Four inbred chicken lines: two resistant (lines 6 and N) and two susceptible (lines 7 and P) to Marek's…
Comparison
Marek's disease virus (MDV) infection vs Resistant versus susceptible chicken lines
Design
Preclinical
Follow-up
>10 days postinfection
Authors
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May link IL-6/IL-18 to MDV lymphoma susceptibility in chickens; hypothesis-generating and requires independent validation.
IL-6 and IL-18 may play a crucial role in driving immune responses that lead to lymphomas in susceptible chickens following Marek's disease virus infection.
Kaiser et al. (2002) studied Marek's Disease Virus (MDV) infection (n=180). Marek's Disease Virus (MDV) infection vs. Uninfected age-matched controls was evaluated on Cytokine mRNA expression (IL-6 and IL-18) and viral load in splenocytes. Following Marek's disease virus infection, splenocytes from susceptible chicken lines expressed high levels of IL-6 and IL-18 mRNA during the early cytolytic phase, whereas resistant lines expressed neither.
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