Key result
Vaccination and subsequent MDV infection induced significantly higher frequencies of IFN-gamma producing MEQ- and pp38-specific T cells in MD-resistant chickens compared to susceptible chickens.
Why the study?
The causes of the well-documented association between genetically defined chicken lines and resistance to Marek's disease remain unknown.
p-value: p=<0.001
There is a direct association between the magnitude of T cell responses to pp38 and MEQ of MDV antigens and genetic resistance to Marek's disease in chickens.
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Links T cell magnitude to MD resistance in chickens; hypothesis-generating for targeted vaccine strategies.
Boodhoo et al. (2022) studied Marek's Disease Virus (MDV) infection (n=200). Marek's Disease Virus (MDV) infection and/or vaccination vs. Mock inoculated (non-infected CEF) was evaluated on Frequencies of IFN-gamma producing pp38 and MEQ-specific T cell responses (p=<0.001). Vaccination and subsequent MDV infection induced significantly higher frequencies of IFN-gamma producing MEQ- and pp38-specific T cells in MD-resistant chickens compared to susceptible chickens.
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