The Differential Diagnosis of Hypercalcemia

Editorial Notes1 May 1972The Differential Diagnosis of HypercalcemiaURIEL S. BARZEL, M.D.URIEL S. BARZEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-825_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe differential diagnosis of hypercalcemia may be a difficult problem for the practicing physician and one with which he is confronted more frequently now that multichannel analysis of serum is widely practiced and more cases of hypercalcemia, often asymptomatic, are uncovered.The major problem has been the differentiation of hyperparathyroidism from other causes of hypercalcemia. The diagnostic maneuvers have included various indexes of phosphate excretion and cortisone suppression tests, and have not always separated the two categories. Recently described relationships among serum calcium levels, acid-base blood variables, and the degree of parathyroid hormone activity seem to provide a new avenue...References1. BARZEL U: Parathyroid hormone, blood phosphorus, and acid-base metabolism. Lancet 1:1329-1331, 1971 CrossrefMedlineGoogle Scholar2. NORDIN B: The effect of intravenous parathyroid extract on urinary pH, bicarbonate and electrolyte excretion. Clin Sci 19:311-319, 1960 MedlineGoogle Scholar3. MULDOWNEYDONOHOECARROLL FJD: Reversible renal bicarbonate wastage in primary and secondary hyperparathyroidism (abstract). The American Society of Nephrology, 5th Annual Meeting, Washington, D.C., 22-23 November 1971 Google Scholar4. NEUMANNEUMAN WM: The chemical dynamics of bone mineral. Chicago, University of Chicago Press, 1958 Google Scholar5. VAES G: On the mechanisms of bone resorption. The action of parathyroid hormone on the excretion and synthesis of lysosomal enzymes and on the extracellular release of acid by bone cells. J Cell Biol 39:676-697, 1968 CrossrefMedlineGoogle Scholar6. HELLMANAUBARTTER DWF: Evidence for a direct effect of parathyroid hormone on urinary acidification. Am J Physiol 209:643-650, 1965 CrossrefMedlineGoogle Scholar7. BARZEL U: Systemic alkalosis in hypoparathyroidism. J Clin Endocrinol Metab 29:917-918, 1969 CrossrefMedlineGoogle Scholar8. WILLSMCGOWAN MG: Plasma chloride levels in hyperparathyroidism and other hypercalcaemic states. Br Med J 1:1153-1156, 1964 CrossrefMedlineGoogle Scholar9. LAFFERTY F: Pseudohyperparathyroidism. Medicine (Baltimore) 45:247-260, 1966 CrossrefMedlineGoogle Scholar10. DOLMANBARZEL MU: Primary hyperparathyroidism: its diagnosis and treatment. NY State J Med 71:1201-1204, 1971 MedlineGoogle Scholar11. HEINEMANN H: Metabolic alkalosis in patients with hypercalcemia. Metabolism 14:1137-1152, 1965 CrossrefMedlineGoogle Scholar12. VERBANCK M: Le fonctionnement du rein dans les etats d'hypercalcemie. Acta Clin Belg 1 (suppl):1-130, 1965 Google Scholar13. WILLS M: Value of plasma chloride concentration and acid-base status in the differential diagnosis of hyperparathyroidism from other causes of hypercalcaemia. J Clin Pathol 24:219-227, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: URIEL S. BARZEL, M.D.Affiliations: Metabolic Endocrine Laboratory Department of Medicine Montefiore Hospital and Medical Center Albert Einstein College of Medicine Bronx, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byParaneoplastische OsteopathieParaneoplastische OsteopathieHYPERCALCEMIA OF IMMOBILIZATION IN NEUROLOGICALLY INJURED CHILDREN: A PROSPECTIVE STUDYProstaglandin-mediated hypercalcemia: A paraneoplastic syndromeHypokalemia and HypercalcemiaDAVID A. NARDONE, M.D.Case 34-1976Effects of extracellular fluid volume contraction and expansion on the bicarbonaturia of parathyroid hormoneDISTANT MANIFESTATIONS OF COLONIC CARCINOMAThe Chloride-Phosphate Ratio in HypercalcemiaFRED J. PALMER, M.D., JERALD C. NELSON, M.D., F.A.C.P., HABEEB BACCHUS, M.D., Ph.D., F.A.C.P.Pseudohyperparathyroidism in head and neck tumors 1 May 1972Volume 76, Issue 5Page: 825-826KeywordsBloodCalciumExcretionHypercalcemiaHyperparathyroidismParathyroid hormonePhosphates ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...