Key result
Cisternal lavage significantly reduced the mean percentage of patients meeting systemic inflammatory response syndrome criteria to 14% compared to 23% in matched controls during the first 21 days after aneurysmal subarachnoid hemorrhage.
Why the study?
Aneurysmal subarachnoid hemorrhage frequently triggers systemic inflammatory response syndrome, which is associated with inferior outcomes, prompting assessment of whether intracranial blood clearance attenuates this response.
Does cisternal lavage through stereotactic catheter ventriculocisternostomy reduce systemic inflammatory response syndrome in patients with aneurysmal subarachnoid hemorrhage?
Cohort (n=160)
No
Does cisternal lavage through stereotactic catheter ventriculocisternostomy reduce systemic inflammatory response syndrome in patients with aneurysmal subarachnoid hemorrhage?
Absolute Event Rate: 14% vs 23%
p-value: p=<0.001
Cisternal lavage via stereotactic catheter ventriculocisternostomy significantly reduces the prevalence and severity of systemic inflammatory response syndrome in patients with aneurysmal subarachnoid hemorrhage.
May attenuate post-SAH SIRS via blood clearance; hypothesis-generating and requires prospective trials before practice change.
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Bissolo et al. (2024) conducted a cohort in Aneurysmal subarachnoid hemorrhage (n=160). Stereotactic catheter ventriculocisternostomy (STX-VCS) and cisternal lavage vs. Standard intensive care (matched controls) was evaluated on Mean percentage of patients meeting systemic inflammatory response syndrome (SIRS) criteria during the first 21 days (p=<0.001). Cisternal lavage significantly reduced the mean percentage of patients meeting systemic inflammatory response syndrome criteria to 14% compared to 23% in matched controls during the first 21 days after aneurysmal subarachnoid hemorrhage.
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