Key result
Intravenous magnesium sulfate decreased postoperative pain compared to placebo across multiple studies including 5,858 patients, potentially leading to decreased opioid utilization.
Why the study?
Anesthesia providers use non-opioid medications to decrease opioid use, prompting synthesis of data on intravenous magnesium sulfate versus placebo to safely reduce postoperative pain and opioid utilization.
Does intravenous magnesium sulfate decrease postoperative pain compared to placebo?
Does intravenous magnesium sulfate decrease postoperative pain compared to placebo?
Perioperative intravenous magnesium sulfate can be safely utilized by anesthesia providers as a non-opioid adjunct to decrease postoperative pain and potentially reduce opioid consumption.
Magnesium sulfate may reduce postoperative pain; extends prior meta-analyses with new RCT data.
Anesthesia providers currently use non-opioid medications in the effort to decrease opioid use.In a randomized controlled trial in 1996, it was first discovered that magnesium sulfate decreased postoperative pain.Further studies from 2013 until 2018 compared intravenous magnesium sulfate versus placebo to decrease postoperative pain.These included five systematic reviews, seven randomized controlled trials (RCTs), and one review article which included 5,858 patients.The data gained from these articles was condensed into information for anesthesia providers so they would be able to safely utilize magnesium sulfate to decrease postoperative pain, which could lead to decreased opioid utilization.
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Tracy Beckham (2020) conducted a review in Postoperative pain (n=5,858). Intravenous magnesium sulfate vs. Placebo was evaluated on Postoperative pain. Intravenous magnesium sulfate decreased postoperative pain compared to placebo across multiple studies including 5,858 patients, potentially leading to decreased opioid utilization.
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