Key result
Azilsartan significantly reduced infarct size (40.8% in low dose vs 52.7% in control) and attenuated cardiac remodeling after myocardial infarction in mice, even without lowering blood pressure.
Why the study?
Does azilsartan prevent cardiac remodeling after myocardial infarction in a mouse model?
Does azilsartan prevent cardiac remodeling after myocardial infarction in a mouse model?
Absolute Event Rate: 40.8% vs 52.7%
p-value: p=<0.05
Azilsartan attenuates cardiac remodeling and fibrosis after myocardial infarction in mice, an effect that occurs independently of its blood pressure-lowering properties.
Does not yet inform clinical practice; hypothesis-generating for azilsartan's BP-independent effects post-MI.
After an acute myocardial infarction (MI), neurohumoral systems including renin-angiotensin-aldosterone system (RAAS) are activated which in turn aggravate cardiac remodeling. Angiotensin receptor blockers (ARBs) are useful drugs for suppression of RAAS. The purpose of this study was to evaluate a new ARB, azilsartan, for suppressing cardiac remodeling and progression to heart failure after MI. We created MI by left anterior descending coronary artery ligation in male mice, and these mice were orally administered saline (0.2 mL) in the control group (Group C), 0.1 mg/kg/d of azilsartan in the low dose group (Group L), and 1.0 mg/kg/d in the high dose group (Group H) everyday. Blood pressure was decreased in Group H, but not in Group L, compared to Group C. At 2 weeks after MI creation, infarct size and fibrotic change at the site remote to the myocardial infarcted area were attenuated in Group L and Group H compared to Group C. Echocardiography revealed that cardiac remodeling was suppressed in Group L and Group H compared to Group C. Increases of mRNA expression levels related to fibrotic change were attenuated in Group L and Group H compared to Group C. The new ARB, azilsartan, had a cardiac remodeling suppression effect after MI, and this effect was observed without blood pressure lowering.
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Nakamura et al. (2013) studied Myocardial Infarction. Azilsartan vs. Saline was evaluated on Percent infarct size (p=<0.05). Azilsartan significantly reduced infarct size (40.8% in low dose vs 52.7% in control) and attenuated cardiac remodeling after myocardial infarction in mice, even without lowering blood pressure.
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