Withvery high regioselectivity, 2-morpholino-acrylonitrile (1) is added to aldonitrones to form unstable 5-morpholino-isoxazolidine-5-carbonitriles; the latter generally tend to form a,D-unsaturated carboxylic acid marpholides with ring opening and elimination of hydrogen cyanide.Capto-dative3) substituent effects are a field of considerable current interest1-'.and 7
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Döpp et al. (1983) studied this question.
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