Key result
Exercise increases plasma natriuretic peptide concentrations, which play a counter-regulatory role to lower blood pressure during physical activity, although responses may vary in hypertensive states.
While exercise generally increases natriuretic peptide levels to counter-regulate blood pressure, prolonged exercise (>30 minutes) in hypertensive rat models paradoxically decreases ANP below resting levels.
Exercise-induced natriuretic peptide changes may aid BP regulation; leaves open translation from animal models to clinical hypertension management.
Natriuretic peptide (NP) release is mainly stimulated by stretching of the myocardium. NP causes diuresis, natriuresis and vasodilation. NP release increases during exercise. Increased NP plays a counter-regulatory role in increased blood pressure during exercise and makes it lower. The source of ANP released during exercise seems to depend on the experimental conditions. Exercise affected guanylate cyclase activity in the kidney and adrenals. Plasma NP concentration is increased in the hypertensive state. Also, exercise increases plasma NP concentration. But when hypertensive model rats swim for more than 30 minutes, plasma ANP concentration decreases to below the resting level.
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Kazuhiro Suda (2013) conducted a review in Hypertension and exercise physiology. Exercise vs. Resting state was evaluated on Plasma natriuretic peptide concentration. Exercise increases plasma natriuretic peptide concentrations, which play a counter-regulatory role to lower blood pressure during physical activity, although responses may vary in hypertensive states.
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