January 1, 1987Clinical and Experimental Hypertension

Direct Radioimmunoassay of Human Plasma Atrial Natriuretic Peptide in Various Normal and Pathophysiological States: Increase in Renal and Cardiac Failure During Exercise

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Why the study?

How do exercise, haemodialysis, and various cardiovascular/renal conditions affect plasma ANP concentrations?

Population

Patients undergoing bicycle ergometer electrocardiographic tests for chest pain, patients with renal failure…

Comparison

Exercise (bicycle ergometer) or haemodialysis vs Resting state or pre-dialysis

Design

Cross-sectional

Authors

MMMargaret J. MorrisUNSW Sydney MCM. CainRoyal Children's Hospital ARAndrew E. RussellUniversity of Michigan

Discussion

Member takes

Implication

ANP changes with exercise and dialysis in renal failure may inform pathophysiology; hypothesis-generating and should not change practice.

Structured PICO

How do exercise, haemodialysis, and various cardiovascular/renal conditions affect plasma ANP concentrations?

Population

Patients undergoing bicycle ergometer electrocardiographic tests for chest pain (n=16), patients with renal failure on haemodialysis (n=9), patients with congestive cardiac failure, treated/untreated hypertensive patients, and normotensive subjects.

Intervention

Exercise (bicycle ergometer) or haemodialysis

Comparator

Resting state or pre-dialysis

Outcome

Plasma atrial natriuretic peptide (ANP) concentrationsurrogate

Plasma ANP concentrations are elevated in heart and renal failure, increase further with exercise, and decrease following haemodialysis.

Cite This Study

Morris et al. (1987) studied this question.

synapsesocial.com/papers/6a896edca14d41d02f4321db https://doi.org/10.3109/10641968709161445

Topics

Heart failure HFrEF treatment Hypertension management

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Direct Radioimmunoassay of Human Plasma Atrial Natriuretic Peptide in Various Normal and Pathophysiological States: Increase in Renal and Cardiac Failure During Exercise

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Direct Radioimmunoassay of Human Plasma Atrial Natriuretic Peptide in Various Normal and Pathophysiological States: Increase in Renal and Cardiac Failure During Exercise

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider