The Changes in Plasma Levels of Brain Natriuretic Peptide during Exercise in Patients With Ischemic Heart Disease

Yeon Jae Kim; Shung Chull Chae; Jae Tae Lee

doi:10.4070/kcj.2001.31.7.625

January 1, 2001Sunhwan'gi

The Changes in Plasma Levels of Brain Natriuretic Peptide during Exercise in Patients With Ischemic Heart Disease

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Why the study?

Does the change in plasma BNP level during exercise correlate with ischemic severity in patients with ischemic heart disease?

Structured PICO

Does the change in plasma BNP level during exercise correlate with ischemic severity in patients with ischemic heart disease?

P

Population

63 cases of suspected ischemic heart disease or myocardial infarction, divided into angina pectoris group (n=16, reversible perfusion defect), myocardial infarction group (n=12, fixed perfusion defect), and control group (n=35, no perfusion defect) based on Tc-99m MIBI SPECT findings.

I

Intervention

Treadmill exercise with a modified Bruce protocol and measurement of plasma BNP levels at rest and just after peak exercise.

C

Comparator

Comparison among control group (no perfusion defect), angina pectoris group (reversible perfusion defect), and myocardial infarction group (fixed perfusion defect).

O

Outcome

Changes in plasma BNP levels during exercise and their correlation with the extent of perfusion defect and ischemic severity.surrogate

Changes in plasma BNP levels during exercise correlate with the extent of myocardial perfusion defects, suggesting its potential utility as an index of ischemic severity.

Limitations

Small sample size
Correlations were analyzed for the entire patient population rather than individually within each group

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Implication

Exercise BNP changes associate with ischemic severity in IHD; hypothesis-generating and requires prospective validation before clinical use.

Abstract

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Cite This Study

Kim et al. (2001) studied this question.

synapsesocial.com/papers/6a9571327fee368366829989 https://doi.org/10.4070/kcj.2001.31.7.625

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The Changes in Plasma Levels of Brain Natriuretic Peptide during Exercise in Patients With Ischemic Heart Disease

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

The Changes in Plasma Levels of Brain Natriuretic Peptide during Exercise in Patients With Ischemic Heart Disease

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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