Association of N-Terminal Pro-Brain Natriuretic Peptide with Cognitive Function and Depression in Elderly People with Type 2 Diabetes
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Key result
In older adults with type 2 diabetes, being in the highest quintile of plasma NT-proBNP was associated with increased odds of reduced cognitive ability (OR 1.80) after adjusting for age and sex.
Why the study?
Is raised plasma NT-proBNP associated with cognitive impairment and depression in elderly patients with type 2 diabetes?
Population
1066 men and women aged 60-75 with type 2 diabetes from the Edinburgh Type 2 Diabetes Study (ET2DS)
Comparison
Plasma NT-proBNP levels vs Lower vs higher NT-proBNP levels
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
NT-proBNP should not yet inform cognitive assessment in elderly T2D; cross-sectional data leave open independent value beyond vascular covariates.
Study Design
Type
Cross-Sectional (n=1,066)
Multicenter
No
Structured PICO
Is raised plasma NT-proBNP associated with cognitive impairment and depression in elderly patients with type 2 diabetes?
P
Population
1,066 community-dwelling older adults aged 60 to 75 years with type 2 diabetes, assessed cross-sectionally to evaluate the association of NT-proBNP with cognitive function and depression.
E
Exposure
Plasma NT-proBNP levels
C
Comparator
Lower vs higher NT-proBNP levels (e.g., extreme quintiles)
O
Outcome
Cognitive function (standardised general cognitive ability factor 'g') and depression (Hospital Anxiety and Depression Scale [HADS])patient reported
Main Result
Odds Ratio: 1.8 (95% CI 1.2–2.7)
p-value: p=0.005
In elderly patients with type 2 diabetes, NT-proBNP is weakly associated with cognitive dysfunction and depression, but this relationship is largely explained by shared vascular and diabetes-related covariates.
Limitations
- Cross-sectional nature of the study makes the direction of the reported associations unclear.
- A large number of analyses were carried out, increasing the possibility of type I errors.
- The clinical relevance of the relatively weak multivariate associations is debatable.
Cite This Study
Feinkohl et al. (2012) conducted a cross-sectional in Type 2 Diabetes (n=1,066). Raised plasma NT-proBNP (highest quintile) vs. Lower NT-proBNP levels (lower four quintiles) was evaluated on Reduced cognitive ability (lowest tertile of general cognitive ability factor 'g') (OR 1.80, 95% CI 1.20-2.70, p=0.005). In older adults with type 2 diabetes, being in the highest quintile of plasma NT-proBNP was associated with increased odds of reduced cognitive ability (OR 1.80) after adjusting for age and sex.
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