What question did this study set out to answer?

To determine whether receptors required for local activin B activity are expressed in human adipose tissue and evaluate how their expression relates to obesity and metabolic markers.

March 10, 2009Biochemical and Biophysical Research CommunicationsOpen Access

ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease

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Authors

LCLena CarlssonNorthwestern University PJPeter JacobsonUniversity of Michigan AWAndrew J. WalleySt George's, University of London

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Implication

Cross-sectional sibling-pair study reveals reduced adipose ALK7 expression in obese individuals, suggesting activin B signaling regulates metabolic health.

Key Points

To determine whether receptors required for local activin B activity are expressed in human adipose tissue and evaluate how their expression relates to obesity and metabolic markers.
Conducted microarray analysis across human tissues to assess the expression profile of activin type I and II receptors.
Quantified adipose tissue ALK7 and INHBB expression in obesity-discordant siblings from the SOS Sib Pair study (n=90 lean, n=90 obese subjects).
Assessed statistical correlations between ALK7 expression, body fat distribution, carbohydrate metabolism, and lipid measures.
Microarray analysis established that ALK7 expression was specific to adipose tissue among the activin receptors evaluated.
Adipose tissue ALK7 expression was significantly higher in lean individuals compared to obese siblings (n=90 lean vs n=90 obese, p=4 x 10^(-31)).
Adipose ALK7 expression correlated with indices of body fat, carbohydrate metabolism, and lipids, while ALK7 and INHBB correlated exclusively in lean subjects and those with normal glucose tolerance.

Cite This Study

Carlsson et al. (2009) studied this question.

synapsesocial.com/papers/6a9574371fe04514d10f5e77 https://doi.org/10.1016/j.bbrc.2009.03.014

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Implication

Cross-sectional sibling-pair study reveals reduced adipose ALK7 expression in obese individuals, suggesting activin B signaling regulates metabolic health.

ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease

Discussion

Member takes

Implication

Key Points

Cite This Study

ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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