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April 1, 1942Biochemical JournalOpen Access

Analogues of pantothenic acid

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Authors

JBJean BarnettRoyal London HospitalFRFred RobinsonDurham University

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Implication

Theoretical analysis highlights the antimetabolite mechanism of sulphanilamide analogues in bacteria, suggesting enzyme interference underlies bacteriostatic action.

Key Points

  • Examine the theoretical mechanisms underlying the bacteriostatic action of sulphanilamide and analogues of pantothenic acid.
  • Evaluated prevailing biochemical theories regarding the bacteriostatic properties of sulphanilamide and related chemical analogues.
  • Identifies enzyme interference and antimetabolite action as the most widely supported explanation for the bacteriostatic effect of sulphanilamide.
  • Positions the competitive disruption of bacterial enzyme systems by nutrient analogues as the primary model for growth inhibition.

Cite This Study

Barnett et al. (1942) studied this question.

synapsesocial.com/papers/6a95745ebfa5337e2a0f38c9https://doi.org/10.1042/bj0360364
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Also Consider

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