Population
Mice with floxed alleles of the IFNAR1 chain of the IFN-α/β receptor, cultured macrophages, and dendritic…
Design
Preclinical
Key result
IRF-3 and IRF-7 work in concert to initiate antiviral responses that restrict murine norovirus replication in vivo and are required for induction of IFN-α/β in macrophages.
Authors
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Animal data identify IRF-3/7 as innate immunity targets; leaves open translation to human norovirus or clinical use.
Expression of the IFN-α/β receptor on macrophages/neutrophils and dendritic cells, along with IRF-3 and IRF-7, is critical for innate immune responses to norovirus infection.
Thackray et al. (2012) studied Norovirus infection. IRF-3 and IRF-7 expression was evaluated on Murine norovirus replication. IRF-3 and IRF-7 work in concert to initiate antiviral responses that restrict murine norovirus replication in vivo and are required for induction of IFN-α/β in macrophages.