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January 12, 2017Journal of VirologyOpen Access

Ifnlr1 depletion in IECs largely recapitulated the phenotype seen in Ifnlr1-/- mice, resulting in higher intestinal tissue viral titers and increased viral shedding in the stool upon murine norovirus or reovirus infection.

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Population

Mice with lineage-specific deletion of the receptor for IFN-λ on intestinal epithelial cells, Ifnlr1-null…

Comparison

Infection with murine norovirus or reovirus and… vs Ifnlr1-null mice

Design

Preclinical

Authors

MBMegan T. BaldridgeSLSanghyun LeeJBJudy J. Brown

Discussion

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Overview

Findings in mice confirm IEC-specific Ifnlr1 requirement against enteric viruses; hypothesis-generating for human IFN-λ therapies.

Structured PICO

P
Population
Mice with lineage-specific deletion of the receptor for IFN-λ (Ifnlr1) on intestinal epithelial cells (IECs), Ifnlr1-null mice, and Rag1-deficient mice
I
Intervention
Infection with murine norovirus (MNoV) or reovirus and exposure to endogenous or exogenous IFN-λ
C
Comparator
Ifnlr1-null mice (and implicitly wild-type controls)
O
Outcome
Intestinal tissue viral titers and fecal viral sheddingsurrogate

Expression of the IFN-λ receptor (Ifnlr1) on intestinal epithelial cells is essential for the antiviral effects of IFN-λ against enteric viruses like norovirus and reovirus.

Cite This Study

Baldridge et al. (2017) studied this question.

synapsesocial.com/papers/6a8257c0546f28f189795e24https://doi.org/10.1128/jvi.02079-16
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Also Consider

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  1. 1IFN-λ determines the intestinal epithelial antiviral host defense2011 · 423 citations
  2. 2IFN-λ derived from nonsusceptible enterocytes acts on tuft cells to limit persistent norovirus2023 · 26 citations
  3. 3Interferon-Lambda: A Potent Regulator of Intestinal Viral Infections2017 · 79 citations
  4. 4Interferon-λ cures persistent murine norovirus infection in the absence of adaptive immunity2014 · 353 citations
  5. 5Critical Role for Interferon Regulatory Factor 3 (IRF-3) and IRF-7 in Type I Interferon-Mediated Control of Murine Norovirus Replication2012 · 88 citations